Assessment of the interstitial volume in healthy volunteers. An equilibrium contrast CMR study

نویسندگان

  • Daniel Sado
  • Viviana Maestrini
  • Andrew Flett
  • Steven K White
  • Sanjay M Banypersad
  • Jonathan Hasleton
  • Graham Sado
  • James Moon
چکیده

Methods 86 healthy subjects (median age 45, range 24-81, 42 males) were recruited from hospital, university or via a local General Practitioner surgery. All were assessed with a cardiac history and examination, routine blood tests, 12 lead ECG, blood pressure and clinical CMR. Volunteers were excluded if any evidence of cardiovascular disease was found. Baseline differences between male and female volunteers were found, with the latter having a faster heart rate, smaller left ventricular volumes, shorter height, lower weight and lower hematocrit.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Comparison of T1 mapping techniques for ECV quantification. Histological validation and reproducibility of ShMOLLI versus multibreath-hold T1 quantification equilibrium contrast CMR

BACKGROUND Myocardial extracellular volume (ECV) is elevated in fibrosis or infiltration and can be quantified by measuring the haematocrit with pre and post contrast T1 at sufficient contrast equilibrium. Equilibrium CMR (EQ-CMR), using a bolus-infusion protocol, has been shown to provide robust measurements of ECV using a multibreath-hold T1 pulse sequence. Newer, faster sequences for T1 mapp...

متن کامل

Cardiac T1 mapping in congenital heart disease: bolus versus infusion protocol for measurement of myocardial extracellular volume

Background Measurement of myocardial extracellular volume fraction (ECV) with T1 mapping cardiac magnetic resonance (CMR) before and after the application of a gadolinium-based extracellular contrast agent enables the assessment of diffuse myocardial fibrosis. The equilibrium between blood and myocardium contrast concentration required for ECV measurements can be achieved with a primed contrast...

متن کامل

Assessment of myocardial and LV blood pool post-contrast T1 evolution: comparison between healthy subjects and patients with hypertrophic cardiomyopathy

Background The choice of post contrast acquisition time is crucial to optimize T1 mapping. Indeed, equilibrium is required for a reliable characterization of interstitial myocardial fibrosis. The majority of studies regarding T1 equilibrium were performed on healthy subjects. Accordingly, the aims of our study were 1) to assess post-contrast T1 Kinetics in HCM patients, in comparison to healthy...

متن کامل

Cardiac amyloid burden assessment by T1 mapping predicts survival in patients with systemic AL amyloidosis - a 2 year follow-up study

Background Cardiac involvement drives outcome in systemic AL amyloidosis. Late gadolinium enhancement (LGE) CMR is useful for the detection of cardiac amyloid, but characteristic LGE patterns do not always occur or may appear late in the disease. Using CMR T1 mapping, we measured the pre contrast myocardial T1 and myocardial Extracellular Volume (ECV), reflecting myocardial amyloidosis burden a...

متن کامل

Variable myocardial interstitial expansion by T1 mapping within LGE area in infarction and hypertrophic cardiomyopathy

Methods 75 patients were prospectively enrolled: “Chronic MI": 6 months after myocardial infarction (n=25); “HCM” hypertrophic cardiomyopathy (n=25), and healthy volunteers (n=25). Patients with HCM and no LGE were excluded. As the conditions for dynamic contrast equilibrium are not reached in infarction, equilibrium contrast was performed. The T1 mapping sequence was ShMOLLI. The contrast agen...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره 14  شماره 

صفحات  -

تاریخ انتشار 2012